The Investigation Protective Effect of Tarantula Cubensis Extract in Rats Induced Experimental Gentamicin Nephrotoxicity

Gentamicin (GM), which is used in the treatment of infections caused by gram-negative bacteria, has limited clinical use due to its serious nephrotoxic side effects. Tarantula cubensis extract (TCE) a homeopathic product that widely and proven be effective veterinary medicine benefit from regeneration, demarcation, antiphlogistic resorptive The aim study was investigate possible protective effects TCE against these negative Gentamicin, one drugs trigger formation free radicals body, terms oxidative stress, apoptosis antioxidant parameters. In this study, rats were divided into four equal groups. Groups; Control, GM, TCE, GM+TCE. Blood kidney tissue samples taken 24 hours after last injection. Urea creatinine analysis performed serum, MDA, SOD TAS serum samples. Bcl-2 Bax analyzes histopathological evaluations tissue. An increase urea levels, decrease levels observed GM group compared control group. On other hand, GM+TCE group, increasing parameters an observed. immunohistochemical examination tissue, it determined pathological disorders increased (decrease Bcl-2, Bax) decreased with application. conclusion, light data we believe high-dose gentamicin causes kidneys, while may have antioxidant, antiapoptotic, curative However, additional studies are needed confirm assumption.